Since the last decades, invasive candidiasis has posed a serious threat to patients in the hospital environment. If untreated, such infections can result in severe diseases such as endocarditis, peritonitis or even meningitis. Suppressed immune status, underlying malignant conditions and the prolonged use of antimicrobial therapies are serious predisposing factors for infection. Among the species from the genus Candida, C. albicans is responsible for the majority of diseases, although the incidence of other, ‘non-albicans’ Candida (NAC) species is also rising. As C. parapsilosis is often the second or third most commonly isolated NAC species from the nosocomial environment and threatens especially the neonates, this pathogen is in the center of our attention. In our laboratory, we use various approaches in order to understand the virulence of C. parapsilosis and the host immune responses induced by this species. These include the investigation of the molecular background of pathogenicity, examining the role of pattern recognition receptors (PRRs) in the immunological recognition of C. parapsilosis, studying inflammasome activation and the role of fungal secreted hydrolytic enzymes in immune evasion, along with investigation of antifungal drug resistance mechanisms.