Publications

2017

Nagy LG, Toth R, Kiss E, Slot J, Gacser A, Kovacs GM (2017) Six Key Traits of Fungi: Their Evolutionary Origins and Genetic Bases. Microbiol Spectr 5

Cillingova A, Zeman I, Toth R, Nebohacova M, Dunckova I, Holcova M, Jakubkova M, Gerecova G, Pryszcz LP, Tomaska L, Gabaldon T, Gacser A, Nosek J (2017) Eukaryotic transporters for hydroxyderivatives of benzoic acid. Sci Rep 7: 8998

Csonka K, Vadovics M, Marton A, Vagvolgyi C, Zajta E, Toth A, Toth R, Vizler C, Tiszlavicz L, Mora-Montes HM, Gacser A (2017) Investigation of OCH1 in the Virulence of Candida parapsilosis Using a New Neonatal Mouse Model. Front Microbiol 8: 1197

Toth A, Zajta E, Csonka K, Vagvolgyi C, Netea MG, Gacser A (2017) Specific pathways mediating inflammasome activation by Candida parapsilosis. Sci Rep 7: 43129

 

2016

Berkovits C, Toth A, Szenzenstein J, Deak T, Urban E, Gacser A, Nagy K (2016) Analysis of oral yeast microflora in patients with oral squamous cell carcinoma. Springerplus 5: 1257

Gacser A (2016) Adhesins in Candida parapsilosis: Understudied players in virulence. Virulence 7: 65-67

Gaspar R, Pipicz M, Hawchar F, Kovacs D, Djirackor L, Gorbe A, Varga ZV, Kiricsi M, Petrovski G, Gacser A, Csonka C, Csont T (2016) The cytoprotective effect of biglycan core protein involves Toll-like receptor 4 signaling in cardiomyocytes. J Mol Cell Cardiol 99: 138-150

Mora-Montes HM, Gacser A (2016) Editorial: Recent Advances in the Study of the Host-Fungus Interaction. Front Microbiol 7: 1694

Perez-Garcia LA, Csonka K, Flores-Carreon A, Estrada-Mata E, Mellado-Mojica E, Nemeth T, Lopez-Ramirez LA, Toth R, Lopez MG, Vizler C, Marton A, Toth A, Nosanchuk JD, Gacser A, Mora-Montes HM (2016) Role of Protein Glycosylation in Candida parapsilosis Cell Wall Integrity and Host Interaction. Front Microbiol 7: 306

Toth R, Toth A, Vagvolgyi C, Gacser A (2016) Candida parapsilosis secreted lipase as an important virulence factor. Curr Protein Pept Sci

 

2015

Pryszcz LP, Nemeth T, Saus E, Ksiezopolska E, Hegedusova E, Nosek J, Wolfe KH, Gacser A, Gabaldon T (2015) The Genomic Aftermath of Hybridization in the Opportunistic Pathogen Candida metapsilosis. PLoS Genet 11: e1005626

Grozer Z, Toth A, Toth R, Kecskemeti A, Vagvolgyi C, Nosanchuk JD, Szekeres A, Gacser A (2015) Candida parapsilosis produces prostaglandins from exogenous arachidonic acid and OLE2 is not required for their synthesis. Virulence 6: 85-92

Toth R, Alonso MF, Bain JM, Vagvolgyi C, Erwig LP, Gacser A (2015) Different Candida parapsilosis clinical isolates and lipase deficient strain trigger an altered cellular immune response. Front Microbiol 6: 1102

Estrada-Mata E, Navarro-Arias MJ, Perez-Garcia LA, Mellado-Mojica E, Lopez MG, Csonka K, Gacser A, Mora-Montes HM (2015) Members of the Candida parapsilosis Complex and Candida albicans are Differentially Recognized by Human Peripheral Blood Mononuclear Cells. Front Microbiol 6: 1527

 

2014

Toth R, Toth A, Papp C, Jankovics F, Vagvolgyi C, Alonso MF, Bain JM, Erwig LP, Gacser A (2014) Kinetic studies of Candida parapsilosis phagocytosis by macrophages and detection of intracellular survival mechanisms. Front Microbiol 5: 633

Nagy LG, Ohm RA, Kovacs GM, Floudas D, Riley R, Gacser A, Sipiczki M, Davis JM, Doty SL, de Hoog GS, Lang BF, Spatafora JW, Martin FM, Grigoriev IV, Hibbett DS (2014) Latent homology and convergent regulatory evolution underlies the repeated emergence of yeasts. Nat Commun 5: 4471

Holland LM, Schroder MS, Turner SA, Taff H, Andes D, Grozer Z, Gacser A, Ames L, Haynes K, Higgins DG, Butler G (2014) Comparative phenotypic analysis of the major fungal pathogens Candida parapsilosis and Candida albicans. PLoS Pathog 10: e1004365

Pryszcz LP, Nemeth T, Gacser A, Gabaldon T (2014) Genome comparison of Candida orthopsilosis clinical strains reveals the existence of hybrids between two distinct subspecies. Genome Biol Evol 6: 1069-1078

Pallagi P, Balla Z, Singh AK, Dosa S, Ivanyi B, Kukor Z, Toth A, Riederer B, Liu Y, Engelhardt R, Jarmay K, Szabo A, Janovszky A, Perides G, Venglovecz V, Maleth J, Wittmann T, Takacs T, Gray MA, Gacser A, Hegyi P, Seidler U, Rakonczay Z, Jr. (2014) The role of pancreatic ductal secretion in protection against acute pancreatitis in mice*. Crit Care Med 42: e177-188

Singaravelu K, Gacser A, Nosanchuk JD (2014) Genetic determinants of virulence – Candida parapsilosis. Rev Iberoam Micol 31: 16-21

Gacser A, Tiszlavicz Z, Nemeth T, Seprenyi G, Mandi Y (2014) Induction of human defensins by intestinal Caco-2 cells after interactions with opportunistic Candida species. Microbes Infect 16: 80-85

 

2013

Toth A, Csonka K, Jacobs C, Vagvolgyi C, Nosanchuk JD, Netea MG, Gacser A (2013) Candida albicans and Candida parapsilosis induce different T-cell responses in human peripheral blood mononuclear cells. J Infect Dis 208: 690-698

Pryszcz LP, Nemeth T, Gacser A, Gabaldon T (2013) Unexpected genomic variability in clinical and environmental strains of the pathogenic yeast Candida parapsilosis. Genome Biol Evol 5: 2382-2392

Nemeth T, Toth A, Szenzenstein J, Horvath P, Nosanchuk JD, Grozer Z, Toth R, Papp C, Hamari Z, Vagvolgyi C, Gacser A (2013) Characterization of virulence properties in the C. parapsilosis sensu lato species. PLoS One 8: e68704

Connolly LA, Riccombeni A, Grozer Z, Holland LM, Lynch DB, Andes DR, Gacser A, Butler G (2013) The APSES transcription factor Efg1 is a global regulator that controls morphogenesis and biofilm formation in Candida parapsilosis. Mol Microbiol 90: 36-53

Szenzenstein J, Gacser A, Grozer Z, Farkas Z, Nagy K, Vagvolgyi C, Marki-Zay J, Pfeiffer I (2013) Differential sensitivity of the species of Candida parapsilosis sensu lato complex against statins. Mycopathologia 176: 211-217

Pammi M, Holland L, Butler G, Gacser A, Bliss JM (2013) Candida parapsilosis is a significant neonatal pathogen: a systematic review and meta-analysis. Pediatr Infect Dis J 32: e206-216

 

2012

Valach M, Pryszcz LP, Tomaska L, Gacser A, Gabaldon T, Nosek J (2012) Mitochondrial genome variability within the Candida parapsilosis species complex. Mitochondrion 12: 514-519

Voigt CA, Schafer W, Salomon S (2005) A secreted lipase of Fusarium graminearum is a virulence factor required for infection of cereals. Plant J 42: 364-375

Horvath P, Nosanchuk JD, Hamari Z, Vagvolgyi C, Gacser A (2012) The identification of gene duplication and the role of secreted aspartyl proteinase 1 in Candida parapsilosis virulence. J Infect Dis 205: 923-933

 

2011

Nguyen LN, Gacser A, Nosanchuk JD (2011a) Secreted lipases supply fatty acids for yeast growth in the absence of de novo fatty acid synthesis. Virulence 2: 538-541

Nguyen LN, Gacser A, Nosanchuk JD (2011b) The stearoyl-coenzyme A desaturase 1 is essential for virulence and membrane stress in Candida parapsilosis through unsaturated fatty acid production. Infect Immun 79: 136-145

Nguyen LN, Hamari Z, Kadereit B, Trofa D, Agovino M, Martinez LR, Gacser A, Silver DL, Nosanchuk JD (2011c) Candida parapsilosis fat storage-inducing transmembrane (FIT) protein 2 regulates lipid droplet formation and impacts virulence. Microbes Infect 13: 663-672

 

2009

Trofa D, Agovino M, Stehr F, Schafer W, Rykunov D, Fiser A, Hamari Z, Nosanchuk JD, Gacser A (2009) Acetylsalicylic acid (aspirin) reduces damage to reconstituted human tissues infected with Candida species by inhibiting extracellular fungal lipases. Microbes Infect 11: 1131-1139

Nosek J, Holesova Z, Kosa P, Gacser A, Tomaska L (2009) Biology and genetics of the pathogenic yeast Candida parapsilosis. Curr Genet 55: 497-509

Martinez LR, Mihu MR, Gacser A, Santambrogio L, Nosanchuk JD (2009) Methamphetamine enhances histoplasmosis by immunosuppression of the host. J Infect Dis 200: 131-141

 

2008

Trofa D, Gacser A, Nosanchuk JD (2008) Candida parapsilosis, an emerging fungal pathogen. Clin Microbiol Rev 21: 606-625

Talloczy Z, Martinez J, Joset D, Ray Y, Gacser A, Toussi S, Mizushima N, Nosanchuk JD, Goldstein H, Loike J, Sulzer D, Santambrogio L (2008) Methamphetamine inhibits antigen processing, presentation, and phagocytosis. PLoS Pathog 4: e28

Shi L, Albuquerque PC, Lazar-Molnar E, Wang X, Santambrogio L, Gacser A, Nosanchuk JD (2008) A monoclonal antibody to Histoplasma capsulatum alters the intracellular fate of the fungus in murine macrophages. Eukaryot Cell 7: 1109-1117

Nosanchuk JD, Gacser A (2008) Histoplasma capsulatum at the host-pathogen interface. Microbes Infect 10: 973-977

Lazar-Molnar E, Gacser A, Freeman GJ, Almo SC, Nathenson SG, Nosanchuk JD (2008) The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum. Proc Natl Acad Sci U S A 105: 2658-2663

 

2007

Martinez LR, Ntiamoah P, Gacser A, Casadevall A, Nosanchuk JD (2007) Voriconazole inhibits melanization in Cryptococcus neoformans. Antimicrob Agents Chemother 51: 4396-4400

Gacser A, Schafer W, Nosanchuk JS, Salomon S, Nosanchuk JD (2007a) Virulence of Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis in reconstituted human tissue models. Fungal Genet Biol 44: 1336-1341

Gacser A, Stehr F, Kroger C, Kredics L, Schafer W, Nosanchuk JD (2007b) Lipase 8 affects the pathogenesis of Candida albicans. Infect Immun 75: 4710-4718

Gacser A, Trofa D, Schafer W, Nosanchuk JD (2007c) Targeted gene deletion in Candida parapsilosis demonstrates the role of secreted lipase in virulence. J Clin Invest 117: 3049-3058

 

2005

Gacser A, Salomon S, Schafer W (2005) Direct transformation of a clinical isolate of Candida parapsilosis using a dominant selection marker. FEMS Microbiol Lett 245: 117-121