Project title : Inflammasome activatin and Syk signaling triggered by Candida parapsilosis

My work involves exploring inflammasome activation cause by Candida parapsilosis (see above in Adél Tóth’s section).

A recently started project focuses on Syk (spleen tyrosine kinase). It is most well-known for mediating classical immunoreceptor signaling; however, it is also crucial in multiple innate immunological processes. Recognition of fungal pathogens by the innate immune system is heavily dependent on Syk mediated sinaling. This is initiated by C-type lectin receptors Dectin-1, Dectin-2 and Mincle which bind fungal cell wall components such as β-glucans and N-linked mannans.

Within this new project, my aim is to study the role of Syk mediated signaling during Candida parapsilosis infection.